Nat Immunol. 2001 Jul;2(7):573-4.

ICOS costimulation: It's not just for TH2 cells anymore.

Source

Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. asperlin@medicine.bsd.uchicago.edu

Abstract

A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.

Comment on

Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. [Nat Immunol. 2001]
Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos JC, Amaral J, Qin S, Rottman JB, Coyle AJ, Hancock WW. Nat Immunol. 2001 Jul; 2(7):591-6.
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. [Nat Immunol. 2001]
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses.Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottman JB, Lora J, Al-garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ. Nat Immunol. 2001 Jul; 2(7):597-604.
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. [Nat Immunol. 2001]
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.Rottman JB, Smith T, Tonra JR, Ganley K, Bloom T, Silva R, Pierce B, Gutierrez-Ramos JC, Ozkaynak E, Coyle AJ. Nat Immunol. 2001 Jul; 2(7):605-11.

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ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling. [J Immunol. 2005]
ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.
Watanabe M, Watanabe S, Hara Y, Harada Y, Kubo M, Tanabe K, Toma H, Abe R. J Immunol. 2005 Feb 15; 174(4):1989-96.
ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement. [J Immunol. 2001]
ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement.
Riley JL, Blair PJ, Musser JT, Abe R, Tezuka K, Tsuji T, June CH. J Immunol. 2001 Apr 15; 166(8):4943-8.
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. [Immunity. 2000]
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.
Coyle AJ, Lehar S, Lloyd C, Tian J, Delaney T, Manning S, Nguyen T, Burwell T, Schneider H, Gonzalo JA, et al. Immunity. 2000 Jul; 13(1):95-105.
Review Transcriptional regulation of Th1/Th2 polarization. [Immunol Today. 2000]
Review Transcriptional regulation of Th1/Th2 polarization.
Rengarajan J, Szabo SJ, Glimcher LH. Immunol Today. 2000 Oct; 21(10):479-83.
Review T helper subset development: roles of instruction, selection, and transcription. [J Clin Invest. 2002]
Review T helper subset development: roles of instruction, selection, and transcription.
Farrar JD, Asnagli H, Murphy KM. J Clin Invest. 2002 Feb; 109(4):431-5.

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Cited by 7 PubMed Central articles

The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation. [Haematologica. 2010]
The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation.
Marafioti T, Paterson JC, Ballabio E, Chott A, Natkunam Y, Rodriguez-Justo M, Plonquet A, Rodriguez-Pinilla SM, Klapper W, Hansmann ML, et al. Haematologica. 2010 Mar; 95(3):432-9.
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. [Nat Immunol. 2009]
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. Nat Immunol. 2009 Feb; 10(2):167-75. Epub 2008 Dec 21.
Review Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). [Philos Trans R Soc Lond B Biol...]
Review Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
Blazar BR, Murphy WJ. Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29; 360(1461):1747-67.

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