Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2001 Jul;22(7):394-400.

Dendritic cells as a tool to induce anergic and regulatory T cells.

Author information

  • 1Dept of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany.

Abstract

The induction of antigen-specific T-cell tolerance in the thymus and its maintenance in the periphery is crucial for the prevention of autoimmunity. As well as their stimulatory functions, there is growing evidence that dendritic cells, acting as professional antigen-presenting cells, also maintain and regulate T-cell tolerance in the periphery. This control function is exerted by certain maturation stages and subsets of different ontogeny, and can be influenced by immunomodulatory agents. What is the current state of knowledge of the "immunoregulatory" properties of dendritic cells and how might tolerance-inducing dendritic cells be relevant to therapeutic applications in humans?

Comment in

PMID:
11429324
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk