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Am J Hematol. 2001 Jan;66(1):64-6.

T-gamma gene rearrangement and CMV mononucleosis.

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  • 1Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555-0565, USA. pamathew@utmb.edu

Abstract

A clonal T-gamma rearrangement was found in peripheral blood and bone marrow in a 57-year-old female who presented with 6-week history of fevers, night sweats, and weight loss. Splenomegaly, hemolytic anemia, atypical lymphocytosis, a marrow lymphoid aggregate, and elevated LDH had suggested lymphoproliferative disease. However, IgM serology for cytomegalovirus (CMV) was positive. With observation alone, her clinical features improved over 4 weeks with normalization of the blood count and disappearance of CMV viremia and the aberrant T-gamma clone. Acute CMV infection may mimic lymphoproliferative disease. T-gamma gene rearrangement may be part of the immune response to CMV infection and is not specific to lymphoid neoplasia.

PMID:
11426498
[PubMed - indexed for MEDLINE]
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