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Bioorg Med Chem Lett. 2001 Jul 9;11(13):1699-701.

Antioxidant activity of water-soluble chitosan derivatives.

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  • 1Department of Chemistry, Yuquan Campus, Zhejiang University, 310027, Hangzhou, China.


Water-soluble chitosan derivatives were prepared by graft copolymerization of maleic acid sodium onto hydroxypropyl chitosan and carboxymethyl chitosan sodium. Their scavenging activities against hydroxyl radical *OH were investigated by chemiluminescence technique. They exhibit IC(50) values ranging from 246 to 498 microg/mL, which should be attributed to their different contents of hydroxyl and amino groups and different substituting groups.

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