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Nat Rev Mol Cell Biol. 2001 Jan;2(1):63-7.

Breaking the mitochondrial barrier.

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  • 1Departement de Biologie Cellulaire, Sciences III, 30 quai Ernest Ansermet, 1211 Genève 4, Switzerland.


Pro- and anti-apoptotic members of the Bcl-2 family control the permeability of the outer mitochondrial membrane. They could do this either by forming autonomous pores in the membrane or by collaborating with components of the permeability transition pore. Here we discuss why we favour the first of these possibilities.

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