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Trends Biochem Sci. 2001 Jun;26(6):345-7.

The Brix domain protein family -- a key to the ribosomal biogenesis pathway?

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  • 1Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, A-1030 Vienna, Rep. Austria.


Six (one archaean and five eukaryotic) protein families have similar domain architecture that includes a central globular Brix domain, and optional N- and obligatory C-terminal segments, both with charged low-complexity regions. Biological data for some proteins in this superfamily suggest a role in ribosome biogenesis and rRNA binding.

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