Curr Opin Immunol. 2001 Jun;13(3):317-25.

Tec kinases: modulators of lymphocyte signaling and development.

Lewis CM, Broussard C, Czar MJ, Schwartzberg PL.

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National Human Genome Research Institute, National Institutes of Health, 20892, Bethesda, MD, USA.

Abstract

The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-gamma and downstream pathways.

PMID:: 11406363; [PubMed - indexed for MEDLINE]

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