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Curr Opin Neurobiol. 2001 Jun;11(3):369-77.

Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors.

Author information

  • 1Laboratoire de Neurobiologie Mol├ęculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France.

Erratum in

  • Curr Opin Neurobiol 2001 Aug;11(4):521.


Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the acetylcholine-binding sites and the ion channel in signal transduction.

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