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Curr Opin Neurobiol. 2001 Jun;11(3):320-6.

How does calcium trigger neurotransmitter release?

Author information

  • Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA. georgea@neuro.duke.edu


Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.

[PubMed - indexed for MEDLINE]
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