Neuroradiology. 2001 May;43(5):379-82.

The effects of cidofovir on progressive multifocal leukoencephalopathy: an MRI case study.

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Physics Department, Texas Technical University, Lubbock 79409, USA. vckrc@ttu.edu

Abstract

MRI was used to study the effects of introducing cidofovir (HPMPC, Vistide) to the antiretroviral therapy of a 33-year-old white man diagnosed as having progressive multifocal leukoencephalopathy (PML) secondary to AIDS. In response to combined cidofovir and antiretroviral therapy he showed significant clinical improvement. MRI showed a decrease in extent of existing lesions, without new ones. Blood chemistry information obtained indicated some involvement of immunologic mechanisms: the CD4:8 ratio showed improvement from an average of 0.08 before treatment to 0.13 during therapy.

PMID:: 11396742; [PubMed - indexed for MEDLINE]

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