Display Settings:

Format

Send to:

Choose Destination
Crit Rev Immunol. 2000;20(6):433-50.

Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other".

Author information

  • 1Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA.

Abstract

It is increasingly clear that immunity to "self"-antigens may result in tumor destruction in mouse and man. But which antigens should be targeted with therapeutic cancer vaccines? In the case of melanoma, recognition of melanocyte differentiation antigens (MDA) can be associated with autoimmune depigmentation (vitiligo). We propose that intersection of protein transport to melanosomes and endosomes allows for the loading of MDA-derived peptides on MHC class II molecules, resulting in the activation of MDA-specific CD4+ "helper" T cells that aid the induction of melanoma-specific CD8+ T cells. Thus, the immunogenicity of MDA may be a consequence of their unique cell biology. Studies of MDA-based vaccines can provide new insight into the development of more effective cancer vaccines.

PMID:
11396680
[PubMed - indexed for MEDLINE]
PMCID:
PMC2543120
Free PMC Article

Images from this publication.See all images (5)Free text

FIGURE 1
FIGURE 2
FIGURE 3
FIGURE 4
FIGURE 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk