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Anticancer Res. 2001 Mar-Apr;21(2B):1355-8.

Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients.

Author information

  • 1Second Department of Surgery, Democritus Thrace University, Medical School, 68100 Alexandroupolis, Greece. akarayan@usa.net

Abstract

BACKGROUND:

Tumour necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine associated with cancer-related cachexia. In this study we evaluated serum levels of TNF-alpha in pancreatic cancer patients and investigated their relationships to cachexia.

PATIENTS AND METHODS:

Serum TNF-alpha levels were determined in 63 patients with pancreatic cancer using an enzyme immunoassay specific for human TNF-alpha.

RESULTS:

Serum TNF-alpha levels were detected in 36.5% of patients. Patients with metastatic disease showed significantly higher positive serum TNF-alpha rate compared to those with non-metastatic disease. Patients with detectable serum TNF-alpha levels had significantly lower body weight and body mass index, lower haematocrit and haemoglobin values, and lower serum total protein and albumin levels compared to those with undetectable TNF-alpha levels. Serum TNF-alpha levels were inversely correlated with body weight, body mass index, haematocrit, haemoglobin, and serum protein and albumin levels.

CONCLUSIONS:

TNF-alpha levels are detectable in the serum of pancreatic cancer patients, particularly in those with advanced disease, and these levels correlate with poor nutritional status.

PMID:
11396212
[PubMed - indexed for MEDLINE]
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