Annu Rev Biochem. 2001;70:777-810.

Mechanisms of viral membrane fusion and its inhibition.

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Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, M.I.T., Cambridge, Massachusetts 02142, USA. Eckert@wi.mit.edu

Abstract

Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.

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Mechanisms of viral membrane fusion and its inhibition.

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