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Clin Infect Dis. 2001 Jul 1;33 Suppl 1:S38-46.

Diagnosis and management of posttransplant lymphoproliferative disorder in solid-organ transplant recipients.

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  • 1Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.


The Epstein-Barr virus (EBV) has a pivotal pathophysiologic role in the development of most lymphoproliferative disorders that occur after solid-organ transplantation. The term "EBV-associated posttransplant lymphoproliferative disorder" (PTLD) includes all clinical syndromes of EBV-associated lymphoproliferation, ranging from uncomplicated posttransplant infectious mononucleosis to true malignancies that contain clonal chromosomal abnormalities. PTLDs are historically associated with a high mortality rate in patients who have a monoclonal form of the disorder. Recently described approaches to pathology, diagnosis, treatment, and preventive strategies of PTLD, however, have the potential to improve outcome.

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