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Nat Rev Mol Cell Biol. 2001 Jun;2(6):457-66.

Living dangerously: how Helicobacter pylori survives in the human stomach.

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  • 1Centro CNR Biomembrane e Dipartimento di Scienze Biomediche, Universit√† di Padova, Via G. Colombo 3, 35121 Padova, Italy.


Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche--the human stomach.

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