Biochim Biophys Acta. 1975 Apr 29;386(2):538-41.

Hemoglobin Atlanta or alpha 2 beta 2 75 Leu-Pro (E19): an unstable variant found in several members of a Caucasian family.

Hubbard M, Winton EF, Lindeman JG, Dessauer PL, Wilson JB, Wrightstone RN, Huisman TH.

Abstract

Hemoglobin Atlanta, alpha 2 beta 2 75 Leu-Pro (E19), has been found in several members of three generations of a Caucasian family living in metropolitan Atlanta. The abnormal hemoglobin is one of the nine unstable variants in which either a leucyl or an alanyl residue is replaced by a prolyl residue. These substitutions have been observed in the B, E, F, and G helixes of the beta chain and in the H helix of the alpha-chain. Hemoglobin Atlanta heterozygotes are mildly affected by the presence of this unstable hemoglobin.

PMID:: 1138885; [PubMed - indexed for MEDLINE]

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A Dutch family with Hb Atlanta [beta 75(E19)Leu-->Pro]. [Hemoglobin. 1996]
A Dutch family with Hb Atlanta [beta 75(E19)Leu-->Pro].
Aygün V, van Zwieten R, Pronk-Admiraal CJ, Ponjee GA, de Regt J, Harteveld CL, Giordano PC, Roos D. Hemoglobin. 1996 Nov; 20(4):351-9.
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Review [The unstable hemoglobin disease].
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Cited by 1 PubMed Central article

beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0]. [Proc Natl Acad Sci U S A. 1981]
beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0].
Adams JG 3rd, Steinberg MH, Newman MV, Morrison WT, Benz EJ Jr, Iyer R. Proc Natl Acad Sci U S A. 1981 Jan; 78(1):469-73.

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Hemoglobin Atlanta or alpha 2 beta 2 75 Leu-Pro (E19): an unstable variant found in several members of a Caucasian family.

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