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Genome Biol. 2001;2(5):REVIEWS3007. Epub 2001 Apr 27.

The Rab GTPase family.

Author information

  • 1Department of Biochemistry, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway. stenmark@ulrik.uio.no

Abstract

SUMMARY:

The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion.

PMID:
11387043
[PubMed - indexed for MEDLINE]
PMCID:
PMC138937
Free PMC Article

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