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1: Genome Biol. 2001;2(5):REVIEWS1015. Epub 2001 Apr 26.Click here to read Click here to read Links

Morpholino antisense oligonucleotides: tools for investigating vertebrate development.

Corey DR, Abrams JM.

Departments of Pharmacology and Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA. david.corey@utsouthwestern.edu

Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.

PMID: 11387041 [PubMed - indexed for MEDLINE]

PMCID: PMC138935