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Lab Anim (NY). 2001 May;30(5):34-9.

The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases.

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  • Jackson Laboratory Library, 600 Main St., Bar Harbor, ME 04609-1500, USA.

Abstract

In recent years, the use of genetically altered mice as models of complex human disease has revolutionized biomedical research into the genetics of disease pathogenesis and potential therapeutic interventions. Whether a mouse expresses a spontaneous or induced mutation, it is critical to remember that the observed phenotype is not always the direct result of the genetic alteration. The author points out the importance of considering the genetic background of the strain used to create these important models.

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  • Background noise. [Lab Anim (NY). 2001]
PMID:
11385732
[PubMed - indexed for MEDLINE]

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