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    Nat Med. 2001 Jun;7(6):725-31.

    Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

    Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S.

    Source

    Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

    Abstract

    Surface-contact-mediated signaling induced by the measles virus (MV) fusion and hemagglutinin glycoproteins is necessary and sufficient to induce T-cell unresponsiveness in vitro and in vivo. To define the intracellular pathways involved, we analyzed interleukin (IL)-2R signaling in primary human T cells and in Kit-225 cells. Unlike IL-2-dependent activation of JAK/STAT pathways, activation of Akt kinase was impaired after MV contact both in vitro and in vivo. MV interference with Akt activation was important for immunosuppression, as expression of a catalytically active Akt prevented negative signaling by the MV glycoproteins. Thus, we show here that MV exploits a novel strategy to interfere with T-cell activation during immunosuppression.

    PMID:
    11385511
    [PubMed - indexed for MEDLINE]

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