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Dermatology. 2001;202(3):230-4.

High-dose pulse corticosteroid therapy in the treatment of severe alopecia areata.

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  • 1Department of Dermatology, Saarland University Hospital, Homburg/Saar, Germany.

Abstract

OBJECTIVE:

The present monocenter prospective study was designed to evaluate the efficacy of intravenous high-dose methylprednisolone pulse therapy in patients with severe alopecia areata (AA).

METHODS:

30 patients (aged 14-56 years) were treated with methylprednisolone (8 mg/kg body weight) intravenously on 3 consecutive days at 4-week intervals for at least 3 courses.

RESULTS:

67% of patients with AA plurifocalis showed >50% regrowth of hair. None of the patients with AA totalis or universalis and only 1 patient with ophiasic AA responded to therapy. In patients with AA plurifocalis, higher response rates could be observed in those suffering from long-term disease compared to patients treated during their first episodes of AA (73 vs. 57%).

CONCLUSION:

High-dose methylprednisolone pulse therapy is an effective and well-tolerated treatment for patients with severe AA plurifocalis but might be less beneficial for patients with ophasic AA, AA totalis or universalis.

Copyright 2001 S. Karger AG, Basel

PMID:
11385229
DOI:
51642
[PubMed - indexed for MEDLINE]
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