Display Settings:


Send to:

Choose Destination
Surg Oncol Clin N Am. 2001 Apr;10(2):257-69, vii-viiii.

Seed and soil revisited: contribution of the organ microenvironment to cancer metastasis.

Author information

  • Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. ifidler@mdanderson.org


The outcome of cancer metastasis depends on multiple interactions (cross-talk) between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The organ microenvironment can influence the biology of cancer growth, angiogenesis, and metastasis in several different ways. Therapy of metastasis, therefore, should be targeted against metastatic tumor cells and the homeostatic factors that are favorable to metastasis, growth, and survival of the metastatic cells.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk