Novel HLA allele, HLA-B*4013, identified from a potential bone marrow recipient. Putative gene conversion events with donor sequence

Tissue Antigens. 2001 Apr;57(4):380-3. doi: 10.1034/j.1399-0039.2001.057004380.x.

Abstract

A new B40 allele was identified in a leukemic Caucasian patient. This allele, designated B*4013, differs in alpha 1 domain from B*4002 at six amino acidic positions: 67, 77, 80, 81, 82 and 83. Most of this substitutions could alter the antigen binding site of the HLA-B molecule. B*4013 may have originated by gene conversion or reciprocal recombination involving B*4002 as the recipient allele of sequence donated by B*4406. The new allele was serologically typed as a "blank" associated with the Bw4 epitope.

MeSH terms

  • Alleles*
  • Amino Acid Sequence
  • Base Sequence
  • Bone Marrow Transplantation / immunology*
  • Child
  • Female
  • Gene Conversion / immunology*
  • HLA-B Antigens / genetics*
  • HLA-B40 Antigen
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Male
  • Molecular Sequence Data
  • Tissue Donors

Substances

  • HLA-B Antigens
  • HLA-B*40:13 antigen
  • HLA-B40 Antigen

Associated data

  • GENBANK/U96942