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Br J Haematol. 2001 May;113(2):553-5.

The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden.

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  • 1Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands. S.Middeldorp@amc.uva.nl


The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post-partum period. The absolute risk for pregnancy-related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy-related VTE in women with a symptomatic first-degree relative was 17% per pregnancy (95%CI 4.7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy.

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