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    Neurobiol Aging. 2001 May-Jun;22(3):387-95.

    Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein.

    Johnson RJ, Xiao G, Shanmugaratnam J, Fine RE.

    Source

    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. rjohnson@bu.edu

    Abstract

    Processing of the beta-amyloid precursor protein (APP) in the endoplasmic reticulum and the Golgi apparatus may be critical in generating the beta-amyloid molecules linked to the pathogenesis of Alzheimer's disease. Since chaperone molecules such as calreticulin (Crt) have been shown to be important in the maturation of many glycoproteins, we investigated the interaction between Crt and APP. We show that APP binds transiently to Crt in a manner that is pH, divalent cation, and N-linked glycosylation-dependent. Both immature APP (containing only N-linked sugars) and mature APP (containing both N-linked and O-linked sugars) bind to Crt. Both proteins are part of a complex that appears to be large enough to accommodate other proteins as well. However, while most of the immature form is associated with the complexes, very little of the mature form is. The interaction between APP and Crt is likely to be of physiological significance with respect to APP maturation since Crt is involved in quality control of nascent glycoproteins in the secretory pathway.

    PMID:
    11378243
    [PubMed - indexed for MEDLINE]

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