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Trends Genet. 2001 Jun;17(6):304-6.

Inversions and the dynamics of eukaryotic gene order.

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  • 1EMBL, Biocomputing, Meyerhofstrasse 1, 69117 Heidelberg, Germany. huynen@embl-heidelberg.de


Comparisons of the gene order in closely related genomes reveal a major role for inversions in the genome shuffling process. In contrast to prokaryotes, where the inversions are predominantly large, half of the inversions between Saccharomyces cerevisiae and Candida albicans appear to be small, often encompassing only a single gene. Overall the genome rearrangement rate appears higher in eukaryotes than in prokaryotes, and the current genome data do not indicate that functional constraints on the co-expression of neighboring genes have a large role in conserving eukaryotic gene order. Nevertheless, qualitatively interesting examples of conservation of gene order in eukaryotes can be observed.

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