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Leuk Res. 2001 Jul;25(7):519-28.

Clinical and histopathological aspects of cutaneous mastocytosis.

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  • 1Department of Dermatology, Division of General Dermatology, University of Vienna, Vienna General Hospital, Waehringer Guertel 18-20, 1090 Vienna, Austria.


The organ most frequently involved in mastocytosis is the skin. Cutaneous mastocytosis (CM) is classified according to clinical presentation and is further defined by onset of disease. CM tends to appear early in life but adult onset CM occurs. CM in children has a low incidence of systemic involvement whereas systemic mastocytosis occurs in >25% of CM in adults. Almost all patients with CM belong into the indolent category of the consensus revised classification (Valent et al., Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leukemia Research 2001;25:603-625.) and thus have a good prognosis. CM of infancy and childhood frequently involutes spontaneously, CM of adults does not. The prevalence of the disease is unknown and familiar occurrence is very rare.

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