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Microbes Infect. 2001 May;3(6):493-507.

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells.

Author information

  • 1Department of Gastroenterology, The Royal Alexandra Hospital for Children, PO Box 3515, Parramatta 2124, Westmead NSW, Australia. Tedo@chw.edu.au

Abstract

Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.

PMID:
11377211
[PubMed - indexed for MEDLINE]
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