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    J Endocrinol. 2001 Jun;169(3):595-602.

    Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice.

    Friis-Hansen L, Lacourse KA, Samuelson LC, Holst JJ.

    Department of Clinical Biochemistry, Rigshospitalet, DK-2100 Copenhagen, Denmark. lfh@rh.dk

    The maturation of many peptide hormones is attenuated in carboxypeptidase E (CPE)-deficient fat/fat mice, leading to a slowly developing, adult-onset obesity with mild diabetes. To determine the contribution of the hormones generated from the proglucagon precursor to this phenotype, we studied the tissue-specific processing of glucagon and glucagon-like peptide-1 (GLP-1) in these mice. In all tissues examined there was a great reduction in mature amidated GLP-1. Furthermore, a lack of CPE attenuates prohormone convertase processing of proglucagon in both the pancreas and the intestine. These findings suggest that defects in proglucagon processing together with other endocrine malfunctions could contribute to the diabetic and obesity phenotype in fat/fat mice.

    PMID: 11375130 [PubMed - indexed for MEDLINE]

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    • Glucagon (GlucaGen Diagnostic Kit®)

      Glucagon is a hormone produced in the pancreas. Glucagon is used to raise very low blood sugar. Glucagon is also used in diagnostic testing of the stomach and other digestive organs.

    • Source: AHFS Consumer Medication Information

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