Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar

D Guilet; J J Hélesbeux; D Séraphin; T Sévenet; P Richomme; J Bruneton

doi:10.1021/np000517o

Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar

J Nat Prod. 2001 May;64(5):563-8. doi: 10.1021/np000517o.

Authors

D Guilet¹, J J Hélesbeux, D Séraphin, T Sévenet, P Richomme, J Bruneton

Affiliation

¹ SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49100 Angers, France.

PMID: 11374944
DOI: 10.1021/np000517o

Abstract

Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Coumarins / isolation & purification*
Coumarins / pharmacology
Drug Screening Assays, Antitumor
Fruit / chemistry
Humans
KB Cells
Mass Spectrometry
Plant Epidermis / chemistry
Plants, Medicinal / chemistry*
Spectrophotometry, Ultraviolet

Substances

Antineoplastic Agents, Phytogenic
Coumarins