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Curr Biol. 2001 May 1;11(9):R349-51.

Neuronal differentiation: proneural genes inhibit gliogenesis.

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  • Howard Hughes Medical Institute, Departments of Internal Medicine and Cell and Developmental Biology, 3215 CCGC, University of Michigan, Ann Arbor, Michigan 48109-0934, USA.


Proneural basic helix-loop-helix transcription factors such as Neurogenin are activators of neuronal gene expression. Recent studies show they reinforce neuronal differentiation by also inhibiting the expression of glial genes, and are required in vivo to prevent premature and excessive gliogenesis.

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