AIDS: Research groups from different countries created a case definition for lipodystrophy at a lipodystrophy workshop held in San Diego, CA. According to the definition, symptoms of lipodystrophy may include prominent veins in the legs, breast enlargement, and accumulation of fat on the face and on the back of the neck. Results of several foreign studies on lipodystrophy are presented. The results of two studies suggest that using nucleoside analogue reverse transcriptase inhibitors (NARTIs) may increase the risk for developing lipodystrophy. The incidence of decreased insulin sensitivity and its correlation to anti-HIV drug use was also discussed at the workshop.