AIDS: Donald Abrams is the principal investigator in a prospective, randomized community-based clinical trial conducted by the Community Consortium, University of California, San Francisco. He will conduct a pilot study to evaluate high-, medium- or low-potency smoked marijuana versus dronabinol in stimulating appetite and reducing weight loss associated with HIV-related wasting syndrome. The study will examine changes in weight and lean body mass, CD4 cell counts, appetite, quality of life, and adverse effects. Study background, objectives, methodology and evaluation criteria are summarized.