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BMJ. 2001 May 19;322(7296):1207-9.

Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study.

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  • 1Centre for Adverse Reactions Monitoring and Intensive Medicines Monitoring Programme, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.

Abstract

OBJECTIVES:

To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy.

DESIGN:

Data mining using bayesian statistics implemented in a neural network architecture.

SETTING:

International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring.

MAIN OUTCOME MEASURES:

Reports mentioning antipsychotic drugs, cardiomyopathy, or myocarditis.

RESULTS:

A strong signal existed for an association between clozapine and cardiomyopathy and myocarditis. An association was also seen with other antipsychotics as a group. The association was based on sufficient cases with adequate documentation and apparent lack of confounding to constitute a signal. Associations between myocarditis or cardiomyopathy and lithium, chlorpromazine, fluphenazine, haloperidol, and risperidone need further investigation.

CONCLUSIONS:

Some antipsychotic drugs seem to be linked to cardiomyopathy and myocarditis. The study shows the potential of bayesian neural networks in analysing data on drug safety.

PMID:
11358771
[PubMed - indexed for MEDLINE]
PMCID:
PMC31617
Free PMC Article
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