Eur J Biochem. 2001 May;268(10):2773-8.

p300/CBP/p53 interaction and regulation of the p53 response.

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Department of Adult Oncology and Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. sgrossman@partners.org

Abstract

Substantial evidence points to a critical role for the p300/CREB binding protein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF bind to and acetylate p53 during the DNA damage response, and are needed for full p53 transactivation as well as downstream p53 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP interaction is equally complex. Through physical interaction with p53, p300/CBP can both positively and negatively regulate p53 transactivation, as well as p53 protein turnover depending on cellular context and environmental stimuli, such as DNA damage.

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