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Ann Neurol. 2001 May;49(5):665-8.

Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.

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  • 1Neurogenetics Section, Institute of Neurology, London, UK.


A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.

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