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1: Lancet. 2001 May 5;357(9266):1412-4.Click here to read Links
Comment in:
Lancet. 2001 Sep 1;358(9283):759-60.

Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia.

Carr A, Morey A, Mallon P, Williams D, Thorburn DR.

HIV, Immunology, and Infectious Disease Clinical Services Unit 2010, Sydney, Australia. acarr@stvincents.com.au

Acute hepatitis with lactic acidosis is a life-threatening but reversible toxic effect on mitochondria of HIV-1 nucleoside-analogue treatment. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered from nucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptom free patients who receive nucleoside-analogue therapy should have hepatic function constantly monitored, especially those with past or present lactic acidaemia.

PMID: 11356442 [PubMed - indexed for MEDLINE]

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