Evolution of bioinorganic motifs in P450-containin...[Biochem Soc Trans. 2001]

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1: Biochem Soc Trans. 2001 May;29(Pt 2):139-47. Links

Evolution of bioinorganic motifs in P450-containing systems.

Degtyarenko KN, Kulikova TA.

EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, U.K. kirill@ebi.ac.uk

The choice of bioinorganic motifs by Nature results in a spectacular variety of active-site structures even within the same protein family. Here, we use the concept of the bioinorganic motif to discuss the function and evolution of P450-containing and other related systems. Apart from P450, these systems include a FAD flavoprotein or domain, a FMN domain, ferredoxins and cytochrome b(5). Analysis of available complete genomes can shed light on what an ancestral P450-containing system could be.

PMID: 11356142 [PubMed - indexed for MEDLINE]

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