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J Hum Genet. 2001;46(5):289-92.

Cloning and sequencing of a novel human gene which encodes a putative hydroxylase.

Author information

  • 1Department of Molecular Pathogenesis, Nagoya University School of Medicine, Japan.

Abstract

Using a conventional two-hybrid technique with MAWD as bait protein, a novel full-length cDNA was isolated and sequenced from a human liver cDNA library. This cDNA consists of 2,575 base pairs and has a predicted open reading frame encoding 255 amino acids. Overall, it is similar to the catalytic enzyme PHZF, catalyzing the hydroxylation of phenazine-1-carboxylic acid to 2-hydroxyphenazine-1-carboxylic acid. Polymerase chain reaction-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 10q21.1 near the marker D10S210.

PMID:
11355021
[PubMed - indexed for MEDLINE]
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