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Bioorg Med Chem Lett. 2001 May 7;11(9):1149-52.

The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry.

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  • 1Procter & Gamble Pharmaceuticals, Healthcare Research Center, Mason, OH 45040, USA.


An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.

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