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Antimicrob Agents Chemother. 2001 Jun;45(6):1930-3.

Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa.

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  • 1Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.

Abstract

We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

PMID:
11353657
[PubMed - indexed for MEDLINE]
PMCID:
PMC90577
Free PMC Article

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