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1: Acc Chem Res. 2001 May;34(5):339-49.Click here to read Links

The central enzymes of the aspartate family of amino acid biosynthesis.

Viola RE.

Department of Chemistry, University of Toledo, Toledo, Ohio 43606, USA. ron.viola@utoledo.edu

The aspartate pathway is responsible for the biosynthesis of lysine, threonine, isoleucine, and methionine in most plants and microorganisms. The absence of this pathway in humans and animals makes the central enzymes potential targets for inhibition, with the aim of developing new herbicides and biocides, and also for enhancement, to improve the nutritional value of crops. Our current state of knowledge of these enzymes is reviewed, including recently determined structural information and newly constructed bifunctional fusion enzymes.

PMID: 11352712 [PubMed - indexed for MEDLINE]