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Ann Intern Med. 2001 May 15;134(10):963-7.

Effects of long-term postoperative interferon-alpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial.

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  • 1Second Department of Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

Abstract

BACKGROUND:

Interferon therapy decreases the incidence of hepatocellular carcinoma in patients with chronic hepatitis C.

OBJECTIVE:

To evaluate effects of interferon-alpha on recurrence after resection of hepatitis C virus-related hepatocellular carcinoma.

DESIGN:

Randomized, controlled trial.

SETTING:

University hospital, medical center, and affiliated hospital in Osaka, Japan.

PATIENTS:

30 men were randomly allocated after resection to the interferon-alpha group (n = 15) or the control group (n = 15).

INTERVENTION:

Patients in the interferon-alpha group received interferon-alpha, 6 MIU intramuscularly daily for 2 weeks, then three times weekly for 14 weeks, and finally twice weekly for 88 weeks.

MEASUREMENTS:

Recurrence rates after resection.

RESULTS:

Recurrent tumors were detected in 5 patients in the interferon-alpha group and in 12 control patients. The recurrence rate was significantly lower in the interferon-alpha group than in the control group (P = 0.037).

CONCLUSION:

Postoperative interferon-alpha therapy appears to decrease recurrence after resection of hepatitis C virus-related hepatocellular carcinoma.

PMID:
11352697
[PubMed - indexed for MEDLINE]
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