Biochem Biophys Res Commun. 2001 Apr 13;282(4):853-60.

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.

Source

Department of Molecular and Cellular Biology, Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan. nakayak1@bioreg.kyushu-u.ac.jp

Abstract

The transition from G1 phase to S phase of the mammalian cell cycle is controlled by many positive and negative regulators, among which cyclin E and p27Kip1, respectively, undergo the most marked changes in concentration at this transition. The abundance of both cyclin E and p27Kip1 is regulated predominantly by posttranslational mechanisms, in particular by proteolysis mediated by the ubiquitin-proteasome pathway. Cyclin E and p27Kip1 each bind to and undergo polyubiquitination by the same ubiquitin ligase, known as SCF(Skp2). The degradation of cyclin E and p27Kip1 is greatly impaired in Skp2-deficient mice, resulting in intracellular accumulation of these proteins. In this article, recent progress in characterization of the molecular mechanisms that control the proteolysis of cyclin E and p27Kip1 is reviewed.

PMID:: 11352628; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. [EMBO J. 2000]
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, et al. EMBO J. 2000 May 2; 19(9):2069-81.
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). [Curr Biol. 2001]
PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2).
Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H. Curr Biol. 2001 Feb 20; 11(4):263-7.
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. [J Biol Chem. 2001]
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.
Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S, Nakayama K. J Biol Chem. 2001 Dec 28; 276(52):48937-43. Epub 2001 Oct 26.
Review Ubiquitin-dependent proteolysis and cell cycle control in yeast. [Prog Cell Cycle Res. 1996]
Review Ubiquitin-dependent proteolysis and cell cycle control in yeast.
Chun KT, Mathias N, Goebl MG. Prog Cell Cycle Res. 1996; 2:115-27.
Review Regulation of the G1 to S transition by the ubiquitin pathway. [FEBS Lett. 2001]
Review Regulation of the G1 to S transition by the ubiquitin pathway.
DeSalle LM, Pagano M. FEBS Lett. 2001 Feb 16; 490(3):179-89.

See reviews... See all...

Cited by 32 PubMed Central articles

Review Mcl-1 ubiquitination and destruction. [Oncotarget. 2011]
Review Mcl-1 ubiquitination and destruction.
Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Oncotarget. 2011 Mar; 2(3):239-44.
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. [PLoS One. 2011]
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth.
Li Y, Zhu Z, Zhang S, Yu D, Yu H, Liu L, Cao X, Wang L, Gao H, Zhu M. PLoS One. 2011 Mar 15; 6(3):e17794. Epub 2011 Mar 15.
Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation. [PLoS One. 2011]
Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
Xu Z, Zheng Y, Zhu Y, Kong X, Hu L. PLoS One. 2011 Jan 18; 6(1):e14514. Epub 2011 Jan 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E a...
Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.
Biochem Biophys Res Commun. 2001 Apr 13 ;282(4):853-60.

PubMed
The terminal inverted repeats of IS911: requirements for synaptic complex assemb...
The terminal inverted repeats of IS911: requirements for synaptic complex assembly and activity.
J Mol Biol. 2001 May 18 ;308(5):853-71.

PubMed
Occlusal caries detection in primary teeth: a comparison of DIAGNOdent with conv...
Occlusal caries detection in primary teeth: a comparison of DIAGNOdent with conventional methods.
Br Dent J. 2001 Apr 28 ;190(8):440-3.

PubMed
Metabolism of diethylstilbestrol by rat liver: a preliminary report.
Metabolism of diethylstilbestrol by rat liver: a preliminary report.
J Toxicol Environ Health Suppl. 1976 ;1:37-44.

PubMed
Linear free energy relationships used to evaluate equilibrium partitioning of or...
Linear free energy relationships used to evaluate equilibrium partitioning of organic compounds.
Environ Sci Technol. 2001 Jan 1 ;35(1):1-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: