Phytother Res. 2001 May;15(3):235-9.

Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx.

Burgos RA, Aguila MJ, Santiesteban ET, Sánchez NS, Hancke JL.

Source

Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P.O. Box 567, Valdivia, Chile. rburgos1@uach.cl

Abstract

The possible relaxation of uterine smooth muscle by Andrographis paniculata dried extract via a blockade of voltage operated calcium channels was investigated in rats. Uterine horns pretreated with oestradiol were incubated in Ca(+2) -free Jalon's solution and stimulated with KCl (20-60 mM) in order to produce depolarization of the membrane. The isometric contractile response to 1 mM or cumulative concentrations of CaCl2 were blockaded by 0.2, 0.4 and 0.8 mg/mL of A. paniculata. The maximum contractile response induced by acetylcholine was moderately antagonized by A. paniculata. The possible blockade of Ca(+2) entry by A. paniculata was evaluated with (45)Ca(+2) uptake in uterine rings incubated with free-Ca(+2)-Ringer's solution high in K+ (KCl 40 mM). The influx was completely blockaded with 0.4 mg/mL of A. paniculata. These results strongly suggest that A. paniculata blockades voltage operated calcium channels inhibiting the entry of Ca(+2) from the external medium.

PMID:: 11351359; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens. [J Ethnopharmacol. 2000]
Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens.
Burgos RA, Imilan M, Sánchez NS, Hancke JL. J Ethnopharmacol. 2000 Jul; 71(1-2):115-21.
Effects of resveratrol, a grape polyphenol, on uterine contraction and Ca²+ mobilization in rats in vivo and in vitro. [Endocrinology. 2011]
Effects of resveratrol, a grape polyphenol, on uterine contraction and Ca²+ mobilization in rats in vivo and in vitro.
Hsia SM, Wang KL, Wang PS. Endocrinology. 2011 May; 152(5):2090-9. Epub 2011 Mar 1.
Characteristics of ca influxes through voltage- and receptor-operated Ca channels in uterine smooth muscle. [J Pharmacol Exp Ther. 1984]
Characteristics of ca influxes through voltage- and receptor-operated Ca channels in uterine smooth muscle.
Ichida S, Moriyama M, Terao M. J Pharmacol Exp Ther. 1984 Feb; 228(2):439-45.
Review Calcium antagonists and dysmenorrhea. [Ann N Y Acad Sci. 1988]
Review Calcium antagonists and dysmenorrhea.
Andersson KE. Ann N Y Acad Sci. 1988; 522:747-56.
Review [Advanced study of calcium channel blockers in Chinese herbal medicine]. [Zhong Xi Yi Jie He Za Zhi. 1990]
Review [Advanced study of calcium channel blockers in Chinese herbal medicine].
Gao X. Zhong Xi Yi Jie He Za Zhi. 1990 Jul; 10(7):447-8, 425.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage ...
Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx.
Phytother Res. 2001 May ;15(3):235-9.

PubMed
Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: ...
Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease.
Ann Rheum Dis. 2001 Jun ;60(6):577-84.

PubMed
Developmental expression of neurokinin A and functional neurokinin-2 receptors i...
Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.
Am J Physiol Lung Cell Mol Physiol. 2001 Jun ;280(6):L1348-58.

PubMed
Postexercise nutrient intake timing in humans is critical to recovery of leg glu...
Postexercise nutrient intake timing in humans is critical to recovery of leg glucose and protein homeostasis.
Am J Physiol Endocrinol Metab. 2001 Jun ;280(6):E982-93.

PubMed
How does a "wait and see" approach to prescribing antibiotics for acute otitis m...
How does a "wait and see" approach to prescribing antibiotics for acute otitis media (AOM) compare with immediate antibiotic treatment?
J Fam Pract. 2001 May ;50(5):469.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: