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    Genomics. 2001 May 1;73(3):272-83.

    Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10).

    Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA.

    The Center for Hearing Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA. llustig@bme.jhu.edu

    We report the isolation and initial characterization of a new member of the human nicotinic acetylcholine receptor (nAChR) subunit family, alpha10 (CHRNA10), from both inner-ear neuroepithelium and lymphoid tissue. The cDNA is 1959 nucleotides in length, with a coding region predicting a protein of 451 amino acids that is 90% identical to rat alpha10. The alpha10 gene was localized to chromosome 11p15.5. Human alpha10 was detected in human inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes using reverse transcriptase-polymerase chain reaction, Northern blot hybridization, and immunohistochemistry. We also detected the expression of the human nAChR alpha9 (CHRNA9) mRNA in these same tissues using RT-PCR and Northern blot hybridization. Copyright 2001 Academic Press.

    PMID: 11350119 [PubMed - indexed for MEDLINE]

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