Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine

N E Rowland; M Marshall; K Robertson

doi:10.1016/s0014-2999(01)00958-x

Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine

Eur J Pharmacol. 2001 May 4;419(1):61-4. doi: 10.1016/s0014-2999(01)00958-x.

Authors

N E Rowland¹, M Marshall, K Robertson

Affiliation

¹ Department of Psychology, University of Florida, P.O. Box 112250, Center Drive, Gainesville, FL 32611-2250, USA. nrowland@ufl.edu

PMID: 11348631
DOI: 10.1016/s0014-2999(01)00958-x

Abstract

Free feeding rats given supplementary 1 h access per day to a palatable dessert test meal were tested for the anorectic effect of dehydroepiandrosterone alone or in combination with either the serotonin releasing agent dexfenfluramine or the norepinephrine uptake inhibitor thionisoxetine (LY 368975). Isobolographic analysis showed that the effect of dehydroepiandrosterone combined with either dexfenfluramine or thionisoxetine was within the range predicted for additivity of action.

MeSH terms

Animals
Appetite / drug effects*
Appetite Depressants / pharmacology*
Dehydroepiandrosterone / pharmacology*
Dexfenfluramine / pharmacology*
Dose-Response Relationship, Drug
Drug Combinations
Drug Interactions
Drug Synergism
Eating / drug effects
Female
Fluoxetine / analogs & derivatives*
Fluoxetine / pharmacology*
Male
Rats
Rats, Sprague-Dawley
Serotonin Receptor Agonists / pharmacology

Substances

Appetite Depressants
Drug Combinations
Serotonin Receptor Agonists
Fluoxetine
thionisoxetine
Dehydroepiandrosterone
Dexfenfluramine