Abstract
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the superoxide dismutase concentration was only about 1% of that found in normal porcine liver. These observations indicate that superoxide anion radical is an intermediate in the reduction of iron by xanthine oxidase in vitro but not in vivo.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Diphosphate / analogs & derivatives*
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Adenosine Diphosphate / metabolism
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Animals
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Chlorides
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Ferric Compounds / metabolism
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Ferritins / metabolism*
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Iron / metabolism*
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Liver / enzymology
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Oxidation-Reduction
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Substrate Specificity
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Superoxide Dismutase / metabolism
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Superoxides / metabolism*
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Swine
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Xanthine Oxidase / metabolism*
Substances
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Chlorides
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Ferric Compounds
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adenosine diphosphate-ferric chelate
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Superoxides
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Adenosine Diphosphate
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Ferritins
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Iron
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Superoxide Dismutase
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Xanthine Oxidase
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ferric chloride