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    Proc Natl Acad Sci U S A. 2001 May 22;98(11):6168-73. Epub 2001 May 8.

    Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

    De Zutter GS, Davis RJ.

    Source

    Program in Molecular Medicine and Howard Hughes Medical Institute, University of Massachusetts Medical Center, Worcester, MA 01605, USA.

    Abstract

    Neurotrophic factor deprivation causes apoptosis by a mechanism that requires macromolecular synthesis. This fact suggests that gene expression is necessary to achieve cell death. To identify mRNA that is expressed in apoptotic cells we used subtractive hybridization with cDNA prepared from neuronal pheochromocytoma cells. Monoamine oxidase (MAO) expression was increased in cells during nerve growth factor withdrawal-induced apoptosis. The increased apoptosis and induction of MAO was prevented by inhibition of the p38 mitogen-activated protein (MAP) kinase pathway. MAO may contribute to the apoptotic process because inhibition of MAO activity suppressed cell death. Together, these data indicate that MAO may be a target of pro-apoptotic signal transduction by the p38 MAP kinase pathway.

    PMID:
    11344273
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC33440
    Free PMC Article

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