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Trends Cardiovasc Med. 2000 Oct;10(7):275-8.

Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver.

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  • Department of Internal Medicine, Institute of Clinical Medicine, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 Japan. shimano-tky@umin.ac.jp


Sterol regulatory element-binding proteins (SREBPs) are basic helix-loop-helix (bHLH) type transcription factors that control expression of genes involved in biosynthesis of cholesterol and fatty acids. Dietary studies with normal, transgenic, and knockout mice have established SREBP-1 as a dominant transcription factor regulating gene expression of lipogenic enzyme in the liver. Polyunsaturated fatty acids inhibit hepatic lipogenic enzymes through suppressing SREBP-1. Whereas SREBP-2 exerts sterol regulation through cleavage of the membrane-bound precursor protein to liberate the active nuclear form into the nucleus, SREBP-1 controls lipogenic enzymes by self-regulating its own transcription level. Promoter analysis of the SREBP-1 gene will be important to clarify the mechanism of nutritional regulation of lipogenic genes.

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